| gld and lpr hematopoietic cell transfers: common and different serological features of the C57BL/6 chimeras. | |
| | |
MedLine Citation:
|
PMID: 8098670 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Homozygosity for either the lpr (lymphoproliferation) or the gld (generalized lymphoproliferative disease) mutation in mice causes the development of strikingly similar hyperglobulinemia and lymphoproliferative syndromes. Nevertheless, previous studies of various C57BL/6 chimeras obtained by reconstitution of irradiated recipients with hematopoietic cells (HC), differing at the bg, gld, lpr, and/or nu loci, showed that the lpr and gld syndromes had distinct etiologies. The [lpr-->lpr], [gld-->gld], and [gld-->wild] chimeras developed lymphoid hyperplasia, while the [lpr-->wild, bg, or gld] and [nulpr-->wild or bg] chimeras developed a severe persistent lymphoid aplasia. We now show that the serological status (immunoglobulin (Ig) levels and Ig isotype distribution) of the [lpr-->lpr], [gld-->gld], and [gld-->wild] chimeras were roughly equivalent to those of genetic lpr and gld mice. Despite their lymphoid aplasia, all the [lpr-->non-lpr] chimeras displayed surprisingly normal serum Ig levels, similar to [wild-->wild] control chimeras, although always with some abnormal isotype profile. In fact, an early but transient increase of serum IgG1 levels was found in all [lpr-->wild, bg, or gld], [lpr-->lpr], [nulpr-->wild or bg], [wild-->lpr], and [gld-->wild or gld] types of chimeras. Despite a common early behavior, the host type and/or the gld or lpr HC origin may cause later divergences of the gld or lpr HC grafted chimeras. |
| | |
Authors:
|
D Velin; P Goettelfinger; S Froidevaux; F Loor |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Cellular immunology Volume: 148 ISSN: 0008-8749 ISO Abbreviation: Cell. Immunol. Publication Date: 1993 May |
Date Detail:
|
Created Date: 1993-06-18 Completed Date: 1993-06-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1246405 Medline TA: Cell Immunol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 331-45 Citation Subset: IM |
Affiliation:
|
Laboratoire d'immunologie, Université de Strasbourg, Illkirch, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antibodies, Antinuclear / biosynthesis Antibody Formation* Chimera Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells / physiology* Immunoglobulin Isotypes / biosynthesis Lymphoproliferative Disorders / genetics, immunology*, pathology Mice Mice, Inbred C57BL Mice, Mutant Strains / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Antinuclear; 0/Immunoglobulin Isotypes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Induction of experimental autoimmune thyroiditis in rats with the synthetic peptide (2495-2511) of t...
Next Document: Separation of CD4+ functional responses by peptide dose in Th1 and Th2 subsets expressing the same t...