Document Detail

The gestational timing of pregnancy loss: adaptive strategy?
MedLine Citation:
PMID:  19408286     Owner:  NLM     Status:  MEDLINE    
This commentary links early pregnancy milestones (rescue of the corpus luteum, the luteal-placental shift, and blocking of the spiral arteries) with the pattern of gestation-specific pregnancy loss in humans. The objective is to describe the pattern and present an adaptive hypothesis: that high first trimester pregnancy loss results from selection to reduce the risk of maternal morbidity and mortality associated with human delivery. Specific questions within the broad framework of this hypothesis can be addressed with research in comparative physiology and endocrinology.
Donna Day Baird
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Publication Detail:
Type:  Lectures; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  American journal of human biology : the official journal of the Human Biology Council     Volume:  21     ISSN:  1520-6300     ISO Abbreviation:  Am. J. Hum. Biol.     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-10-19     Completed Date:  2010-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8915029     Medline TA:  Am J Hum Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  725-7     Citation Subset:  IM    
Epidemiology Branch, National Institute of Environmental Health Sciences Research, Triangle Park, North Carolina 27709, USA.
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MeSH Terms
Abortion, Spontaneous*
Adaptation, Physiological*
Chorionic Gonadotropin / genetics
Embryo Implantation / physiology
Pregnancy Maintenance / genetics,  physiology*
Selection, Genetic
Reg. No./Substance:
0/Chorionic Gonadotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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