Document Detail

A germ-free status does not protect from the lethal effects of acute lung damage caused by O,S,S,-trimethyl phosphorodithioate.
MedLine Citation:
PMID:  3738927     Owner:  NLM     Status:  MEDLINE    
To investigate whether a normal resident microbiological flora of conventional rats influences the lethality of chemical-induced lung damage, the pneumotoxin O,S,S-trimethyl phosphorodithioate (OSSMe, 75 or 100 mg/kg, s.c.) was administered to age-matched conventional and germ-free male F344 rats. Microbiological and serological examinations confirmed the germ-free state of the germ-free rats and showed that no specific lung pathogens were present in the conventional rats. As in conventional rats, clinical symptoms and death of OSSMe-treated germ-free rats resulted from respiratory failure. The germ-free rats were not more resistant, but rather more susceptible to OSSMe than conventional rats. Increases in lung weight and histological examination of lung tissue 3 days after dosing with OSSMe (75 mg/kg, s.c.) showed no differences between germ-free and conventional rats. Despite alterations in their nasopharyngeal flora, death in the conventional rats was probably not caused by bacterial superinfection. The higher susceptibility of germ-free rats to OSSMe can be partly attributed to pharmacokinetic differences, since plasma levels of OSSMe decreased more slowly in germ-free than in conventional rats. It is concluded that germ-free rats are not protected from the lethal consequences of acute chemical-induced lung damage.
B Nemery; D K Tucker; S Sparrow
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology letters     Volume:  32     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:    1986 Jul-Aug
Date Detail:
Created Date:  1986-09-25     Completed Date:  1986-09-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  153-62     Citation Subset:  IM    
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MeSH Terms
Germ-Free Life*
Lethal Dose 50
Lung / drug effects*,  microbiology,  pathology
Nasopharynx / microbiology
Organothiophosphorus Compounds / toxicity*
Rats, Inbred F344
Thiophosphoric Acid Esters / metabolism,  toxicity*
Reg. No./Substance:
0/Organothiophosphorus Compounds; 0/Thiophosphoric Acid Esters; 22608-53-3/O,S,S-trimethyl phosphorodithioate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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