| The genus Desmodium (Fabaceae)-traditional uses in Chinese medicine, phytochemistry and pharmacology. | |
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MedLine Citation:
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PMID: 22004895 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ETHNOPHARMACOLOGICAL RELEVANCE: Plants of the genus Desmodium (Fabaceae), such as Desmodium styracifolium (Osbeck) Merr. and Desmodium gyrans (L. f.) DC., have a long history of medical use in Traditional Chinese Medicine to treat various ailments including rheumatism, pyrexia, dysentery, wounds, cough, malaria, hepatitis, hemoptysis, etc. In the theory of Traditional Chinese Medicine, most species have the effect of relieving internal heat or fever, neutralizing toxins, inhibiting pain, invigorating blood circulation, suppressing cough and alleviating dyspnea. MATERIALS AND METHODS: A bibliographic investigation was accomplished by analyzing secondary sources including Chinese Herbal Classics, and worldwide accepted scientific databases (Pubmed, Scopus and Web of Science, SciFinder) were scrutinized for the available information on the ethnopharmacological uses in Chinese medicine, phytochemistry, pharmacology and toxicology of Desmodium species. RESULTS: The genus Desmodium is a large member of the Papilionaceae (Fabaceae) family. It contains about 350 plant species used for both feeding stuffs and herbal medicines, of which only about 30 species have been phytochemically or pharmacologically investigated. Desmodium plant extracts, as well as the active principles, have been experimentally studied for their anti-inflammatory, cytotoxic, antidiabetic, antinephrolithic, antibacterial, and nootropic activities in vitro or in vivo. And so far, a total of 212 compounds have been isolated from 15 Desmodium species and characterized mainly as flavonoids and alkaloids, followed by terpenoids, steroids, phenols, phenylpropanoids, glycosides and a number of volatile oils. The remaining unrevealed species are recorded chiefly in Asia and Africa being used in empirical treatment for various diseases. More than 20 Desmodium species have a long history of medical use as Traditional Chinese Medicine and several have been validated for their traditional medical uses by pharmacological studies. AIM OF THE REVIEW: The present review aims to present an up-to-date and comprehensive information of traditional uses in Chinese medicine, phytochemistry, pharmacological and toxicological studies on Desmodium species. |
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Authors:
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Xueqin Ma; Chengjian Zheng; Changling Hu; Khalid Rahman; Luping Qin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-14 |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: - ISSN: 1872-7573 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China; Department of Pharmaceutical Analysis, School of Pharmacy, NingXia Medical University, 1160 Shenli Street, Yinchuan, 750004, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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