Document Detail

The genotoxicity of nitrilotriacetic acid (NTA) in a somatic mutation and recombination test in Drosophila melanogaster.
MedLine Citation:
PMID:  1901958     Owner:  NLM     Status:  MEDLINE    
The genotoxicity of a chelating agent, the trisodium salt of nitrilotriacetic acid (NTA), was assessed in a somatic mutation and recombination test (SMART) in Drosophila melanogaster employing the wing hair markers mwh and flr3. The experiments were performed in parallel in two different laboratories (Padua, Italy and Schwerzenbach, Switzerland). The effectively absorbed doses of NTA, which was administered by feeding to larvae, were determined by a sensitive method employing [3H]leucine which allowed individual consumption levels to be measured. The particular pattern of clone induction produced by this compound suggests that NTA is active in inducing mitotic recombination and possibly aneuploidy in somatic cells of Drosophila. This is discussed in relation to the data present in the literature regarding the genotoxicity of NTA in a variety of experimental systems.
M Zordan; U Graf; D Singer; C Beltrame; L Dalle Valle; M Osti; R Costa; A G Levis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  262     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-05-22     Completed Date:  1991-05-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  253-61     Citation Subset:  IM    
Department of Biology, University of Padua, Italy.
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MeSH Terms
Chelating Agents / toxicity*
Drosophila melanogaster / drug effects,  genetics
Gene Frequency
Genetic Markers
Mutagenicity Tests
Nitrilotriacetic Acid / toxicity*
Sensitivity and Specificity
Reg. No./Substance:
0/Chelating Agents; 0/Genetic Markers; 139-13-9/Nitrilotriacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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