| The genotoxic and antigenotoxic effects of tannic acid in human lymphocytes. | |
| | |
MedLine Citation:
|
PMID: 21774736 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The genotoxicity of tannic acid (TA, tannin) were investigated using chromosome aberration (CA), sister chromatid exchange (SCE), and micronucleus (MN) test systems in human peripheral lymphocytes. Also, the antigenotoxicity of TA against known mutagen EMS was also examined. The lymphocytes were treated with 1.74 × 10(-5), 3.49 × 10(-5), and 6.98 × 10(-5) µM of TA for 24- and 48-hour treatment periods. For the antigenotoxicity of TA, the lymphocytes were treated with three different concentrations of TA and 2.71 µM of EMS. TA synergically induced the CA alone and with the mixture of EMS. However, TA did not induce the SCE alone, whereas TA and EMS as a mixture also synergically induced SCE. TA alone showed no clear effect on micronucleus formation, and it did not induce the MN when used with EMS as a mixture. In addition, TA showed a synergistic cytotoxic effect by decreasing the mitotic and nuclear division indices. The replication index was decreased at all concentrations for 48 hours of treatment time by TA and EMS as a mixture. |
| | |
Authors:
|
Mehmet Buyukleyla; Sebile Azirak; Eyyup Rencuzogullari; Ayse Yavuz Kocaman; Hasan Basri Ila; Mehmet Topaktas; Cengiz Darici |
Related Documents
:
|
10472626 - Pyrite suspended in artificial sea water catalyzes hydrolysis of adsorbed atp: enhancin... 6163466 - Thymidine catabolism and the reutilization of its degradative products in tetrahymena p... 7052946 - A radiometric technique for the measurement of adenylosuccinate lyase. 2675756 - Selective activity of 5-fluoroorotic acid against plasmodium falciparum in vitro. 11997456 - Carbocyclic fatty acids in plants: biochemical and molecular genetic characterization o... 18608766 - Comfa and comsia 3d-qsar analysis on hydroxamic acid derivatives as urease inhibitors. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-21 |
Journal Detail:
|
Title: Drug and chemical toxicology Volume: - ISSN: 1525-6014 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7801723 Medline TA: Drug Chem Toxicol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Natural and Applied Science Institute, Department of Biology, Çukurova University , Adana , Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Partner support and postpartum depressive symptoms.
Next Document: Isoflurane reduces motile sperm counts in the Sprague-Dawley rat.