Document Detail

A genomic switch at the transition from cell proliferation to terminal differentiation in the Drosophila eye.
MedLine Citation:
PMID:  12408803     Owner:  NLM     Status:  MEDLINE    
Organogenesis involves cell proliferation followed by complex determination and differentiation events that are intricately controlled in time and space. The instructions for these different steps are, to a large degree, implicit in the gene expression profiles of the cells that partake in organogenesis. Combining fluorescence-activated cell sorting and SAGE, we analyzed genomic expression patterns in the developing eye of Drosophila melanogaster. Genomic activity changes as cells pass from an uncommitted proliferating progenitor state through determination and differentiation steps toward a specialized cell fate. Analysis of the upstream sequences of genes specifically expressed during the proliferation phase of eye development implicates the transcription factor DREF and its inhibitor dMLF in the control of cell growth in this organ.
Heinrich Jasper; Vladimir Benes; Ann Atzberger; Silvia Sauer; Wilhelm Ansorge; Dirk Bohmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental cell     Volume:  3     ISSN:  1534-5807     ISO Abbreviation:  Dev. Cell     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-31     Completed Date:  2002-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  511-21     Citation Subset:  IM    
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA.
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MeSH Terms
Drosophila Proteins / genetics*
Drosophila melanogaster / embryology,  genetics
Eye / cytology,  embryology*
Gene Expression Profiling
Gene Expression Regulation, Developmental*
Organogenesis / genetics
Transcription Factors / genetics*
Reg. No./Substance:
0/Dref protein, Drosophila; 0/Drosophila Proteins; 0/Mlf protein, Drosophila; 0/Transcription Factors

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