| A genomic switch at the transition from cell proliferation to terminal differentiation in the Drosophila eye. | |
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MedLine Citation:
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PMID: 12408803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Organogenesis involves cell proliferation followed by complex determination and differentiation events that are intricately controlled in time and space. The instructions for these different steps are, to a large degree, implicit in the gene expression profiles of the cells that partake in organogenesis. Combining fluorescence-activated cell sorting and SAGE, we analyzed genomic expression patterns in the developing eye of Drosophila melanogaster. Genomic activity changes as cells pass from an uncommitted proliferating progenitor state through determination and differentiation steps toward a specialized cell fate. Analysis of the upstream sequences of genes specifically expressed during the proliferation phase of eye development implicates the transcription factor DREF and its inhibitor dMLF in the control of cell growth in this organ. |
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Authors:
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Heinrich Jasper; Vladimir Benes; Ann Atzberger; Silvia Sauer; Wilhelm Ansorge; Dirk Bohmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental cell Volume: 3 ISSN: 1534-5807 ISO Abbreviation: Dev. Cell Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-31 Completed Date: 2002-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101120028 Medline TA: Dev Cell Country: United States |
Other Details:
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Languages: eng Pagination: 511-21 Citation Subset: IM |
Affiliation:
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Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA. henri_jasper@urmc.rochester.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Drosophila Proteins / genetics* Drosophila melanogaster / embryology, genetics Eye / cytology, embryology* Gene Expression Profiling Gene Expression Regulation, Developmental* Organogenesis / genetics Transcription Factors / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Dref protein, Drosophila; 0/Drosophila Proteins; 0/Mlf protein, Drosophila; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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