Document Detail

The genomic response of the Drosophila embryo to JNK signaling.
MedLine Citation:
PMID:  11703947     Owner:  NLM     Status:  MEDLINE    
During Drosophila development, the Jun N-terminal kinase signal transduction pathway regulates morphogenetic tissue closure movements that involve cell shape changes and reorganization of the actin cytoskeleton. We analyzed the genome-wide transcriptional response to activation of the JNK pathway in the Drosophila embryo by serial analysis of gene expression (SAGE) and identified loci encoding cell adhesion molecules and cytoskeletal regulators as JNK responsive genes. The role of one of the upregulated genes, chickadee (chic), encoding a Drosophila profilin, in embryogenesis was analyzed genetically. chic-deficient embryos fail to execute the JNK-mediated cytoskeletal rearrangements during dorsal closure. This study demonstrates a transcriptional mechanism of cytoskeletal regulation and establishes SAGE as an advantageous approach for genomic experiments in the fruitfly.
H Jasper; V Benes; C Schwager; S Sauer; S Clauder-Münster; W Ansorge; D Bohmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental cell     Volume:  1     ISSN:  1534-5807     ISO Abbreviation:  Dev. Cell     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-11-14     Completed Date:  2001-12-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  579-86     Citation Subset:  IM    
European Molecular Biology Laboratory, Heidelberg, Germany.
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MeSH Terms
Actins / metabolism
Cell Adhesion / physiology
Contractile Proteins*
Cytoskeleton / metabolism
Drosophila Proteins
Drosophila melanogaster / embryology*
Embryo, Nonmammalian / embryology
Gene Expression Regulation, Developmental
JNK Mitogen-Activated Protein Kinases*
MAP Kinase Kinase 4
Microfilament Proteins / genetics,  metabolism
Mitogen-Activated Protein Kinase Kinases / genetics,  metabolism*
Signal Transduction / genetics*
Transcription, Genetic / physiology
Reg. No./Substance:
0/Actins; 0/Contractile Proteins; 0/Drosophila Proteins; 0/Microfilament Proteins; 0/Profilins; 0/chickadee protein, Drosophila; EC Mitogen-Activated Protein Kinases; EC Kinase Kinase 4; EC Protein Kinase Kinases

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