Document Detail

The genomes of recombinant inbred lines.
MedLine Citation:
PMID:  15545647     Owner:  NLM     Status:  MEDLINE    
Recombinant inbred lines (RILs) can serve as powerful tools for genetic mapping. Recently, members of the Complex Trait Consortium proposed the development of a large panel of eight-way RILs in the mouse, derived from eight genetically diverse parental strains. Such a panel would be a valuable community resource. The use of such eight-way RILs will require a detailed understanding of the relationship between alleles at linked loci on an RI chromosome. We extend the work of Haldane and Waddington on two-way RILs and describe the map expansion, clustering of breakpoints, and other features of the genomes of multiple-strain RILs as a function of the level of crossover interference in meiosis.
Karl W Broman
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Publication Detail:
Type:  Journal Article     Date:  2004-11-15
Journal Detail:
Title:  Genetics     Volume:  169     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-25     Completed Date:  2005-07-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1133-46     Citation Subset:  IM    
Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205-2179, USA.
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MeSH Terms
Chromosome Breakage
Chromosome Mapping
Crossing Over, Genetic
Linkage (Genetics)
Mice, Inbred Strains / genetics*
Recombination, Genetic*
X Chromosome
Erratum In:
Genetics. 2006 Aug;173(4):2419

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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