| A genome-wide screen for nicotine dependence susceptibility loci. | |
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MedLine Citation:
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PMID: 16671072 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genome-wide model free linkage analysis was conducted for nicotine dependence and tobacco use phenotypes in 607 members of 158 nuclear families consisting of at least two ever smokers (100 or more cigarettes smoked in lifetime). DNA from whole blood was genotyped for 739 autosomal microsatellite polymorphisms with an average inter-marker distance of 4.6 cM. A peak LOD score of 2.7 was observed on chromosome 6 for scores for the Fagerström Test for Nicotine Dependence. Exploratory analyses were conducted to determine whether sequence variation at other loci affected other measures of dependence or tobacco use. Four additional loci with LOD scores of 2.7 or more were associated with alternative measures of nicotine dependence, one with current frequency of use, and one with smoking cessation. Several of the corresponding support intervals were near putative loci reported previously (on chromosomes 6, 7, and 8) while others appear to be novel (on chromosomes 5, 16, and 19). |
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Authors:
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Gary E Swan; Hyman Hops; Kirk C Wilhelmsen; Christina N Lessov-Schlaggar; Li S-C Cheng; Karen S Hudmon; Christopher I Amos; Heidi S Feiler; Huijun Z Ring; Judy A Andrews; Elizabeth Tildesley; Neal Benowitz |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics Volume: 141B ISSN: 1552-4841 ISO Abbreviation: Am. J. Med. Genet. B Neuropsychiatr. Genet. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-25 Completed Date: 2006-08-16 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101235742 Medline TA: Am J Med Genet B Neuropsychiatr Genet Country: United States |
Other Details:
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Languages: eng Pagination: 354-60 Citation Subset: IM |
Affiliation:
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Center for Health Sciences, SRI International, Menlo Park, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Family Health Female Genetic Linkage Genetic Predisposition to Disease / genetics* Genetic Testing / methods Genome, Human* Humans Lod Score Male Microsatellite Repeats / genetics Nuclear Family Pedigree Quantitative Trait Loci / genetics Tobacco Use Disorder / diagnosis, genetics* |
| Grant Support | |
ID/Acronym/Agency:
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DA03706/DA/NIDA NIH HHS; M01 RR000083-37S10426/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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