| A genome-wide scan for tying-up syndrome in Japanese Thoroughbreds. | |
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MedLine Citation:
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PMID: 21070280 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Tying-up syndrome, also known as recurrent exertional rhabdomyolysis in Thoroughbreds, is a common muscle disorder for racehorses. In this study, we performed a multipoint linkage analysis using LOKI based on the Bayesian Markov chain Monte Carlo method using 5 half-sib families (51 affected and 277 nonaffected horses in total), and a genome-wide association study (GWAS) using microsatellites (144 affected and 144 nonaffected horses) to map candidate regions for tying-up syndrome in Japanese Thoroughbreds. The linkage analysis identified one strong L-score (82.45) between the loci UCDEQ411 and COR058 (24.9-27.9 Mb) on ECA12. The GWAS identified two suggestive genomic regions on ECA12 (24.9-27.8 Mb) and ECA20 (29.3-33.5 Mb). Based on both results, the genomic region between UCDEQ411 and TKY499 (24.9-27.8 Mb) on ECA12 was the most significant and was considered as a candidate region for tying-up syndrome in Japanese Thoroughbreds. |
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Authors:
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T Tozaki; K Hirota; S Sugita; N Ishida; T Miyake; H Oki; T Hasegawa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Animal genetics Volume: 41 Suppl 2 ISSN: 1365-2052 ISO Abbreviation: Anim. Genet. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8605704 Medline TA: Anim Genet Country: England |
Other Details:
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Languages: eng Pagination: 80-6 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors, Journal compilation © 2010 Stichting International Foundation for Animal Genetics. |
Affiliation:
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Department of Molecular Genetics, Laboratory of Racing Chemistry, Utsunomiya, Tochigi, Japan. ttozaki@lrc.or.jp |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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