| A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans. | |
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MedLine Citation:
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PMID: 12559684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Evidence for genomic regions influencing systolic and diastolic blood pressure (BP) were assessed in a whole genome linkage analysis in 211 African American and 160 white families as part of the GenNet network of the National Heart, Lung and Blood Institute-sponsored Family Blood Pressure Program. Multipoint regression and variance components linkage methods were used to analyze 372 polymorphic markers. Statistically compelling evidence for linkage (P values .0057 and .00023, respectively) was found on chromosome 1. Our results support the idea that BP regulation is most likely governed by multiple genetic loci, each with a relatively weak effect on BP in the population at large. |
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Authors:
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Bonnie A Thiel; Aravinda Chakravarti; Richard S Cooper; Amy Luke; Sue Lewis; Audrey Lynn; Hemant Tiwari; Nicholas J Schork; Alan B Weder |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of hypertension Volume: 16 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-01-31 Completed Date: 2003-07-22 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 151-3 Citation Subset: IM |
Copyright Information:
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Copyright 2003 American Journal of Hypertension, Ltd. |
Affiliation:
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Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Americans African Continental Ancestry Group / genetics* Blood Pressure / genetics* Databases as Topic European Continental Ancestry Group / genetics* Genome, Human* Government Programs Humans Hypertension / ethnology*, genetics* Linkage (Genetics)* Lod Score Middle Aged National Institutes of Health (U.S.) Siblings United States |
| Grant Support | |
ID/Acronym/Agency:
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HL 45508/HL/NHLBI NIH HHS; HL 47910/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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