| A genome-wide association study of self-rated health. | |
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MedLine Citation:
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PMID: 20707712 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Self-rated health questions have been proven to be a highly reliable and valid measure of overall health as measured by other indicators in many population groups. It also has been shown to be a very good predictor of mortality, chronic or severe diseases, and the need for services, and is positively correlated with clinical assessments. Genetic factors have been estimated to account for 25-64% of the variance in the liability of self-rated health. The aim of the present study was to identify Single Nucleotide Polymorphisms (SNPs) underlying the heritability of self-rated health by conducting a genome-wide association analysis in a large sample of 6,706 Australian individuals aged 18-92. No genome wide significant SNPs associated with self-rated health could be identified, indicating that self-rated health may be influenced by a large number of SNPs with very small effect size. A very large sample will be needed to identify these SNPs. |
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Authors:
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Miriam A Mosing; Karin J H Verweij; Sarah E Medland; Jodie Painter; Scott D Gordon; Andrew C Heath; Pamela A Madden; Grant W Montgomery; Nicholas G Martin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Twin research and human genetics : the official journal of the International Society for Twin Studies Volume: 13 ISSN: 1832-4274 ISO Abbreviation: Twin Res Hum Genet Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2011-02-24 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 101244624 Medline TA: Twin Res Hum Genet Country: Australia |
Other Details:
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Languages: eng Pagination: 398-403 Citation Subset: IM |
Affiliation:
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Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. Miriam.Mosing@qimir.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Australia Female Genome-Wide Association Study Health Status* Humans Male Middle Aged Polymorphism, Single Nucleotide* Self-Assessment* |
| Grant Support | |
ID/Acronym/Agency:
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K05 AA017688-04/AA/NIAAA NIH HHS; R01 AA007535-08/AA/NIAAA NIH HHS; R01 AA010249-04/AA/NIAAA NIH HHS; R01 AA013320-05/AA/NIAAA NIH HHS; R01 AA013321-05/AA/NIAAA NIH HHS; R01 DA012854-08/DA/NIDA NIH HHS; R01 DA012854-09/DA/NIDA NIH HHS; R01 MH066206-05/MH/NIMH NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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