Document Detail


A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
MedLine Citation:
PMID:  23300138     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Tumour biomarkers are used as indicators for cancer screening and as predictors for therapeutic responses and prognoses in cancer patients. We aimed to identify genetic loci that influence concentrations of cancer antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA) and α fetoprotein (AFP), and investigated the associations between the significant single nucleotide polymorphisms (SNPs) with risks of oesophageal squamous cell (OSCC), pancreatic and hepatocellular cancers. DESIGN: We carried out a genome wide association study on plasma CA19-9, CEA and AFP concentrations in 3451 healthy Han Chinese and validated the results in 10 326 individuals. Significant SNPs were further investigated in three case control studies (2031 OSCC cases and 2044 controls; 981 pancreatic cancer cases and 1991 controls; and 348 hepatocellular cancer cases and 359 controls). RESULTS: The analyses showed association peaks on three genetic loci for CA19-9 (FUT6-FUT3 at 19p13.3, FUT2-CA11 at 19q13.3 and B3GNT3 at 19p13.1; p=1.16×10(-13)-3.30×10(-290)); four for CEA (ABO at 9q34.2, FUT6 at 19p13.3, FUT2 at 19q13.3 and FAM3B at 21q22.3; p=3.33×10(-22)-5.81×10(-209)); and two for AFP (AFP at 4q11-q13 and HISPPD2A at 15q15.3; p=3.27×10(-18) and 1.28×10(-14)). These explained 17.14% of the variations in CA19-9, 8.95% in CEA and 0.57% in AFP concentrations. Significant ABO variants were also associated with risk of OSCC and pancreatic cancers, and AFP variants with risk of hepatocellular cancer (p<0.05). CONCLUSIONS: This study identified several loci associated with CA19-9, CEA and AFP concentrations. The ABO variants were associated with risk of OSCC and pancreatic cancers and AFP variants with risk of hepatocellular cancer.
Authors:
Meian He; Chen Wu; Jianfeng Xu; Huan Guo; Handong Yang; Xiaomin Zhang; Jielin Sun; Dianke Yu; Li Zhou; Tao Peng; Yunfeng He; Yong Gao; Jing Yuan; Qifei Deng; Xiayun Dai; Aihua Tan; Yingying Feng; Haiying Zhang; Xinwen Min; Xiaobo Yang; Jiang Zhu; Kan Zhai; Jiang Chang; Xue Qin; Wen Tan; Yanling Hu; Mingjian Lang; Sha Tao; Yuanfeng Li; Yi Li; Junjie Feng; Dongfeng Li; Seong-Tae Kim; Shijun Zhang; Hongxing Zhang; S Lilly Zheng; Lixuan Gui; Youjie Wang; Sheng Wei; Feng Wang; Weimin Fang; Yuan Liang; Yun Zhai; Weihong Chen; Xiaoping Miao; Gangqiao Zhou; Frank B Hu; Dongxin Lin; Zengnan Mo; Tangchun Wu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-7
Journal Detail:
Title:  Gut     Volume:  -     ISSN:  1468-3288     ISO Abbreviation:  Gut     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, , Wuhan, Hubei, China.
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