Document Detail


The genetics of multiple endocrine neoplasia syndromes.
MedLine Citation:
PMID:  1349800     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The familial nature of multiple endocrine neoplasia syndromes (FMEN) has been recognized for some time but little is known about their cause. Recent application of new molecular techniques has mapped FMEN syndromes to specific chromosomes and provided evidence for the mechanism through which neoplasia occurs. In this review, we describe the techniques that led to recent advances in our understanding of FMEN and we discuss the evidence supporting proposed molecular mechanisms of neoplasia.
Authors:
M S Nanes; B D Catherwood
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annual review of medicine     Volume:  43     ISSN:  0066-4219     ISO Abbreviation:  Annu. Rev. Med.     Publication Date:  1992  
Date Detail:
Created Date:  1992-06-11     Completed Date:  1992-06-11     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  2985151R     Medline TA:  Annu Rev Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  253-68     Citation Subset:  IM    
Affiliation:
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Mapping
Heterozygote Detection
Humans
Models, Genetic
Multiple Endocrine Neoplasia / classification,  genetics*
Pedigree
Polymorphism, Restriction Fragment Length
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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