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The genetics of gestational trophoblastic disease: a rare complication of pregnancy.
MedLine Citation:
PMID:  22469506     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Gestational choriocarcinoma is usually a rapidly spreading fatal disease, but it is curable if diagnosed early and treated. It is a unique malignancy that is a partial or complete allograft with a genotype that is not the same as the host genotype. It is most often preceded by an abnormal molar pregnancy. The surprising and unique androgenetic origin of complete hydatidiform molar pregnancies was first revealed by Kajii and Ohama in 1977. We describe the current understanding of the morphology, epidemiology and genetics of gestational trophoblastic disease that followed the milestone findings by Kajii and Ohama.
Authors:
Lori Hoffner; Urvashi Surti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer genetics     Volume:  205     ISSN:  2210-7762     ISO Abbreviation:  Cancer Genet     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-04-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101539150     Medline TA:  Cancer Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  63-77     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Magee-Womens Research Institute and Foundation, Pittsburgh, PA, USA.
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