| The genetics of chronic inflammatory diseases. | |
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MedLine Citation:
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PMID: 19297396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic inflammatory diseases have been at the forefront of the new genome-wide association study era. Conditions such as coeliac disease, type 1 diabetes, Crohn's disease and ulcerative colitis have all benefited with multiple loci identified and replicated for each condition. As cohort sample numbers increase and researchers collaborate and share cohorts, common susceptibility loci are beginning to emerge between several diseases. Crohn's disease and coeliac disease both demonstrate considerable overlap in their common genetic susceptibility with other related conditions. These shared loci offer an insight into the biology of the conditions but still present researchers with the problem of attempting to identify the true causal variants. |
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Authors:
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Graham A Heap; David A van Heel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Human molecular genetics Volume: 18 ISSN: 1460-2083 ISO Abbreviation: Hum. Mol. Genet. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-19 Completed Date: 2009-04-14 Revised Date: 2012-03-08 |
Medline Journal Info:
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Nlm Unique ID: 9208958 Medline TA: Hum Mol Genet Country: England |
Other Details:
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Languages: eng Pagination: R101-6 Citation Subset: IM |
Affiliation:
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Centre for Gastroenterology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Celiac Disease
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genetics*,
immunology Colitis, Ulcerative / genetics*, immunology Crohn Disease / genetics*, immunology Diabetes Mellitus, Type 1 / genetics*, immunology Genetic Predisposition to Disease* Humans |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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