Document Detail


The genetics of behavioral alcohol responses in Drosophila.
MedLine Citation:
PMID:  20813239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Drosophila melanogaster is commonly found near rotting or fermenting fruit, reflected in its name pomace, or vinegar fly. In such environments, flies often encounter significant levels of ethanol. Three observations have made Drosophila a very promising model organism to understand the genetic contributions to the behavioral responses to alcohol. First, similar to higher vertebrates, flies show hyperactivation upon exposure to a low to medium dose of alcohol, while high doses can lead to sedation. In addition, when given a choice, flies will actually prefer alcohol-containing food over regular food. Second, the genes and biochemical pathways implicated in controlling these behavioral responses in flies are also participating in determining alcohol responses, and drinking behavior in mammals. Third, the fact that flies have been studied genetically for over one hundred years means that an exceptional repertoire of genetic tools are at our disposal. Here, we will review some of these tools and experimental approaches, survey the methods for, and measures after Drosophila ethanol exposure, and discuss the different molecular components and functional pathways involved in these behavioral responses to alcohol.
Authors:
Aylin R Rodan; Adrian Rothenfluh
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International review of neurobiology     Volume:  91     ISSN:  0074-7742     ISO Abbreviation:  Int. Rev. Neurobiol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-03     Completed Date:  2010-12-21     Revised Date:  2013-03-07    
Medline Journal Info:
Nlm Unique ID:  0374740     Medline TA:  Int Rev Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-51     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Division of Nephrology, Department of Psychiatry and Program in Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA.
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking / genetics,  physiopathology
Alcoholism / genetics*,  physiopathology*
Animals
Behavior, Animal / classification,  drug effects*,  physiology
Disease Models, Animal
Drosophila
Ethanol / pharmacology*
Gene Expression Regulation / drug effects,  genetics
Humans
Synaptic Transmission / drug effects,  genetics
Grant Support
ID/Acronym/Agency:
R01 AA019526/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
64-17-5/Ethanol
Comments/Corrections

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