Document Detail


A genetically female brain is required for a regular reproductive cycle in chicken brain chimeras.
MedLine Citation:
PMID:  23340412     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Sexual differentiation leads to structural and behavioural differences between males and females. Here we investigate the intrinsic sex identity of the brain by constructing chicken chimeras in which the brain primordium is switched between male and female identities before gonadal development. We find that the female chimeras with male brains display delayed sexual maturation and irregular oviposition cycles, although their behaviour, plasma concentrations of sex steroids and luteinizing hormone levels are normal. The male chimeras with female brains show phenotypes similar to typical cocks. In the perinatal period, oestrogen concentrations in the genetically male brain are higher than those in the genetically female brain. Our study demonstrates that male brain cells retain male sex identity and do not differentiate into female cells to drive the normal oestrous cycle, even when situated in the female hormonal milieu. This is clear evidence for a sex-specific feature that develops independent of gonadal steroids.
Authors:
Fumihiko Maekawa; Miyano Sakurai; Yuki Yamashita; Kohichi Tanaka; Shogo Haraguchi; Kazutoshi Yamamoto; Kazuyoshi Tsutsui; Hidefumi Yoshioka; Shizuko Murakami; Ryo Tadano; Tatsuhiko Goto; Jun-Ichi Shiraishi; Kohei Tomonari; Takao Oka; Ken Ohara; Teruo Maeda; Takashi Bungo; Masaoki Tsudzuki; Hiroko Ohki-Hamazaki
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature communications     Volume:  4     ISSN:  2041-1723     ISO Abbreviation:  Nat Commun     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528555     Medline TA:  Nat Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  1372     Citation Subset:  IM    
Affiliation:
1] Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan [2] Molecular Toxicology Section, Center for Environmental Health Sciences, National Institute for Environmental Studies, Onogawa, Tsukuba, Ibaraki 305-8506, Japan.
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