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A genetic polymorphism in the constant region of rabbit b4 kappa chains.
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MedLine Citation:
PMID:  818336     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Amino acid sequence analysis of a b4 light chain from a rabbit homogeneous antistreptococcal antibody revealed the presence of two amino acid substitutions in the constant region not previously reported for these positions. These interchanges, consisting of serine for alanine at position 121 and leucine for glutamine at position 124, were also present in about 30% of the pooled b4 light chains isolated from pooled IgG from the rabbit (4539) that produced the homogeneous antibody. In addition, these interchanges (b4var) were found, always at the same levels, in varying percentages in nonimmune or early immune bleedings from related rabbits in this pedigreed family and could be traced for five generations. The inheritance pattern of b4var was consistent with autosomal codominant inheritance.
Authors:
J A Sogn; T J Kindt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  143     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1475-82     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Genes*
Immunoglobulin Light Chains* / analysis
Immunoglobulin kappa-Chains* / analysis
Pedigree
Polymorphism, Genetic*
Rabbits
Chemical
Reg. No./Substance:
0/Immunoglobulin Light Chains; 0/Immunoglobulin kappa-Chains
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 6 Year: 1976
Volume: 143 Issue: 6
First Page: 1475 Last Page: 1482
ID: 2190215
Publisher Id: 76192834
PubMed Id: 818336

A genetic polymorphism in the constant region of rabbit b4 kappa chains


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