Document Detail

The genetic and molecular analysis of spe-19, a gene required for sperm activation in Caenorhabditis elegans.
MedLine Citation:
PMID:  15939418     Owner:  NLM     Status:  MEDLINE    
During the process of spermiogenesis (sperm activation) in Caenorhabditis elegans, the dramatic morphological events that ultimately transform round sessile spermatids into polar motile spermatozoa occur without the synthesis of any new gene products. Previous studies have identified four genes (spe-8, spe-12, spe-27 and spe-29) that specifically block spermiogenesis and lead to hermaphrodite-specific fertility defects. Here, we report the cloning and characterization of a new component of the sperm activation pathway, spe-19, that is required for fertility in hermaphrodites. spe-19 is predicted to encode a novel single-pass transmembrane protein. The spe-19 mutant phenotype, genetic interactions and the molecular nature of the gene product suggest SPE-19 to be a candidate for the receptor/co-receptor necessary for the transduction of the activation signal across the sperm plasma membrane.
Brian Geldziler; Indrani Chatterjee; Andrew Singson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental biology     Volume:  283     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-12     Completed Date:  2005-09-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  424-36     Citation Subset:  IM    
Waksman Institute, Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Caenorhabditis elegans / genetics,  physiology*
Caenorhabditis elegans Proteins / genetics*,  metabolism
Cell Membrane / metabolism
Cloning, Molecular
Hermaphroditism / genetics
Membrane Proteins / genetics*,  metabolism
Molecular Sequence Data
Signal Transduction
Spermatogenesis / physiology
Spermatozoa / physiology*
Grant Support
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Membrane Proteins; 0/SPE-19 protein, C elegans

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