Document Detail

A genetic model provides evidence that the receptor for atrial natriuretic peptide (guanylyl cyclase-A) inhibits cardiac ventricular myocyte hypertrophy.
MedLine Citation:
PMID:  11226303     Owner:  NLM     Status:  MEDLINE    
Guanylyl cyclase-A (NPR-A; GC-A) is the major and possibly the only receptor for atrial natriuretic peptide (ANP) or B-type natriuretic peptide. Although mice deficient in GC-A display an elevated blood pressure, the resultant cardiac hypertrophy is much greater than in other mouse models of hypertension. Here we overproduce GC-A in the cardiac myocytes of wild-type or GC-A null animals. Introduction of the GC-A transgene did not alter blood pressure or heart rate as a function of genotype. Cardiac myocyte size was larger (approximately 20%) in GC-A null than in wild-type animals. However, introduction of the GC-A transgene reduced cardiac myocyte size in both wild-type and null mice. Coincident with the reduction in myocyte size, both ANP mRNA and ANP content were significantly reduced by overexpression of GC-A, and this reduction was independent of genotype. This genetic model, therefore, separates a regulation of cardiac myocyte size by blood pressure from local regulation by a GC-mediated pathway.
I Kishimoto; K Rossi; D L Garbers
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Publication Detail:
Type:  Journal Article     Date:  2001-02-13
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  98     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-09-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2703-6     Citation Subset:  IM    
Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9051, USA.
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MeSH Terms
Atrial Natriuretic Factor / genetics,  metabolism
Cardiomegaly / genetics,  prevention & control*
Cells, Cultured
Guanylate Cyclase / genetics,  physiology*
Heart Ventricles / metabolism,  pathology
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Models, Genetic*
RNA, Messenger / genetics
Receptors, Atrial Natriuretic Factor / genetics,  physiology*
Reg. No./Substance:
0/RNA, Messenger; 85637-73-6/Atrial Natriuretic Factor; EC Cyclase; EC, Atrial Natriuretic Factor; EC natriuretic factor receptor A

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