| The genetic manipulation of medicinal and aromatic plants. | |
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MedLine Citation:
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PMID: 17609957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Medicinal and aromatic plants have always been intimately linked with human health and culture. Plant-derived medicines constitute a substantial component of present day human healthcare systems in industrialized as well as developing countries. They are products of plant secondary metabolism and are involved in many other aspects of a plant's interaction with its immediate environment. The genetic manipulation of plants together with the establishment of in vitro plant regeneration systems facilitates efforts to engineer secondary product metabolic pathways. Advances in the cloning of genes involved in relevant pathways, the development of high throughput screening systems for chemical and biological activity, genomics tools and resources, and the recognition of a higher order of regulation of secondary plant metabolism operating at the whole plant level facilitate strategies for the effective manipulation of secondary products in plants. Here, we discuss advances in engineering metabolic pathways for specific classes of compounds in medicinal and aromatic plants and we identify remaining constraints and future prospects in the field. In particular we focus on indole, tropane, nicotine, isoquinoline alcaloids, monoterpenoids such as menthol and related compounds, diterpenoids such as taxol, sequiterpenoids such as artemisinin and aromatic amino acids. |
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Authors:
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Sonia Gómez-Galera; Ana M Pelacho; Anna Gené; Teresa Capell; Paul Christou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-07-03 |
Journal Detail:
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Title: Plant cell reports Volume: 26 ISSN: 0721-7714 ISO Abbreviation: Plant Cell Rep. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-12 Completed Date: 2007-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9880970 Medline TA: Plant Cell Rep Country: Germany |
Other Details:
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Languages: eng Pagination: 1689-715 Citation Subset: IM |
Affiliation:
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Departament de Producció Vegetal i Ciència Forestal, Universitat de Lleida, Av. Alcalde Rovira Roure, 191, 25198, Lleida, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkaloids
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metabolism Hydrocarbons / metabolism Metabolic Networks and Pathways / genetics* Plants, Genetically Modified / chemistry, metabolism* Plants, Medicinal / chemistry, genetics*, metabolism* Technology, Pharmaceutical / methods* |
| Chemical | |
Reg. No./Substance:
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0/Alkaloids; 0/Hydrocarbons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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