Document Detail

A genetic linkage study of the D2 dopamine receptor locus in heavy drinking and alcoholism.
MedLine Citation:
PMID:  8871803     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Reports of an association between restriction fragment length polymorphisms (RFLPs) at the dopamine D2 receptor (DRD2) locus and alcoholism have suggested involvement of that locus in the aetiology of alcoholism. METHOD: Sib pair linkage analyses were conducted in families multiply affected by alcoholism, using both the Taql 'A' RFLP and a microsatellite repeat polymorphism at the DRD2 locus. RESULTS: The 'Identical By Descent' analysis provided significant evidence of an effect of the DRD2 locus on the liability to develop heavy drinking (P < 0.0016) and Research Diagnostic Criteria alcoholism (P < 0.0003) in the first sample of families studied. However, this result was explicable by the segregation of alleles in a single large sibship, and it was not replicated in a second sample of families. CONCLUSIONS: The results do not support linkage between the DRD2 locus and alcoholism in most of the families studied. It remains possible that this locus influences the predisposition to alcoholism in some families.
C C Cook; G Palsson; A Turner; D Holmes; P Brett; D Curtis; H Petursson; H M Gurling
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  169     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-12-31     Completed Date:  1996-12-31     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  243-8     Citation Subset:  IM    
National Addiction Centre, London.
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MeSH Terms
Alcoholism / genetics*
Polymorphism, Genetic
Receptors, Dopamine D2 / genetics*
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Receptors, Dopamine D2

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