Document Detail


A genetic linkage map with 29 loci spanning human chromosome 13q.
MedLine Citation:
PMID:  8100218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A genetic linkage map for the long arm of human chromosome 13 contains 29 loci derived from 38 probe and enzyme combinations and two protein polymorphisms. Thirteen loci form a continuous linkage map of 106 cM in males and 230 cM in females; each was placed on the map with support of at least 1000:1 against alternative orders. On a sex-combined basis, the mean distance between markers is less than 13 cM. The order of loci on the genetic map agrees with physical localization data that show that together these 13 loci cover 13q13 to 13q34. This map was used to regionally localize the 16 remaining loci. The linkage maps reported here should prove to be useful to investigators mapping disease genes and other genetic markers on human chromosome 13.
Authors:
S Gerken; M Leppert; P O'Connell; W Cavenee; C D James; L Ballard; D Stauffer; T Elsner; R Plaetke; J M Lalouel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  16     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-26     Completed Date:  1993-07-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  515-9     Citation Subset:  IM    
Affiliation:
Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84132.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Chromosome Mapping*
Chromosomes, Human, Pair 13*
Female
France
Gene Frequency
Genetic Markers*
Genome, Human*
Humans
Linkage (Genetics)*
Male
Polymorphism, Restriction Fragment Length
Grant Support
ID/Acronym/Agency:
R01-HG00367/HG/NHGRI NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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