Document Detail


The genetic epidemiology of leprosy in a Brazilian population.
MedLine Citation:
PMID:  7726175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Data on leprosy patients have been obtained from the Dispensary of Leprosy of Campinas, São Paulo, where records on practically all cases of leprosy in the Campinas area during the period 1960-70 are filed. The whole sample comprises 10,886 individuals, distributed among 1,568 families. Complex segregation analysis was utilized to determine the nature of the genetic factors that may operate on leprosy and its subtypes. The results suggest the presence of a recessive major gene controlling susceptibility to leprosy per se, with frequency of approximately .05, although there are deviations from the expected Mendelian segregation proportions. Possible etiologic heterogeneity was examined by considering two subtypes separately: for lepromatous leprosy and tuberculoid leprosy there are suggestions for a segregating major effect; however, Mendelian transmission could not be demonstrated in either case. Therefore, there is no evidence to suggest unique genetic determinants for leprosy subtypes.
Authors:
M F Feitosa; I Borecki; H Krieger; B Beiguelman; D C Rao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of human genetics     Volume:  56     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-05-24     Completed Date:  1995-05-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1179-85     Citation Subset:  IM    
Affiliation:
Departamento de Genética, Fundação Oswaldo Cruz, Rio de Janiero, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brazil / epidemiology
Child
Child, Preschool
Female
Genes, Recessive / genetics
Genetic Predisposition to Disease
Humans
Infant
Infant, Newborn
Leprosy / classification,  epidemiology*,  genetics*
Male
Meiosis
Middle Aged
Morbidity
Phenotype
Prevalence
Risk Factors
Grant Support
ID/Acronym/Agency:
GM 28719/GM/NIGMS NIH HHS
Comments/Corrections

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