Document Detail

The genetic epidemiology of joint hypermobility: a population study of female twins.
MedLine Citation:
PMID:  15334479     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To estimate the genetic influence on joint hypermobility in an unselected population using a classic twin study design.
METHODS: A self-report questionnaire on joint hypermobility as well as data on age, height, weight, estrogen replacement therapy, and menopause status were obtained from 483 monozygotic (MZ) and 472 dizygotic (DZ) unselected female twin pairs ages 21-81 years who were registered with the St Thomas' Adult Twin Registry in the UK.
RESULTS: The overall prevalence of hypermobility was 19.5% in MZ twins and 22.1% in DZ twins. The prevalence of hypermobile joints declined with age, falling from 34% in subjects ages 20-30 years to 18.4% in those ages 60 years or older. Significantly greater concordance for joint hypermobility was observed in the MZ twins when compared with the DZ twins (60% versus 36%), consistent with a genetic influence. In variance components analysis, the age- and body mass index-adjusted heritability of joint hypermobility was estimated to be 70% (95% confidence interval 57-89%).
CONCLUSION: Genetic factors have a substantial contribution to joint hypermobility in the adult female population.
Alan J Hakim; Lynn F Cherkas; Rodney Grahame; Tim D Spector; Alexander J MacGregor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  50     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-30     Completed Date:  2004-09-24     Revised Date:  2014-06-17    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2640-4     Citation Subset:  AIM; IM    
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MeSH Terms
Age Factors
Great Britain / epidemiology
Joint Instability / epidemiology*,  genetics*
Middle Aged
Twins, Monozygotic
Grant Support
17489//Arthritis Research UK

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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