Document Detail

A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome.
MedLine Citation:
PMID:  17564628     Owner:  NLM     Status:  MEDLINE    
A pharmacogenetic study suggests the 5-HTT LPR polymorphism predicts response to alosetron, and another study describes a possible association of the GNbeta3 C825T polymorphism with IBS in patients with dyspepsia. We performed a case-control association study to determine whether these polymorphisms are associated with irritable bowel syndrome (IBS). The study aim was to compare allele and genotype frequencies between cases and controls for the 5-HTT LPR and the GNbeta3 C825T polymorphism. Cases were 50 GI outpatients; controls were 53 General Medicine outpatients matched to cases for age, gender and race at a major medical centre. Participants completed a questionnaire and donated blood. DNA was genotyped using polymerase chain reaction based assays. Eighty-two per cent of cases met Rome II criteria for IBS: 12% constipation-, 46% diarrhoea-, and 42% mixed-IBS. Genotype and allele frequencies for both polymorphisms did not differ between cases and controls. However, the allele frequency of the short (S) allele of the 5-HTT LPR polymorphism was greater in those with mixed-IBS compared with controls (68%vs 45%, P < 0.05). This study suggests that the 5-HTT LPR polymorphism may be associated with mixed-IBS, but not IBS overall. No association was observed for the GNbeta3 C825T polymorphism with IBS overall or subtypes.
Y A Saito; G R Locke; J M Zimmerman; G Holtmann; J P Slusser; M de Andrade; G M Petersen; N J Talley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  19     ISSN:  1350-1925     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-13     Completed Date:  2007-07-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  465-70     Citation Subset:  IM    
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
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MeSH Terms
Case-Control Studies
Genetic Predisposition to Disease*
Heterotrimeric GTP-Binding Proteins / genetics*
Irritable Bowel Syndrome / genetics*
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic
Serotonin Plasma Membrane Transport Proteins / genetics*
Grant Support
Reg. No./Substance:
0/G-protein beta3 subunit; 0/Serotonin Plasma Membrane Transport Proteins; EC GTP-Binding Proteins

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