| A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome. | |
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MedLine Citation:
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PMID: 17564628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A pharmacogenetic study suggests the 5-HTT LPR polymorphism predicts response to alosetron, and another study describes a possible association of the GNbeta3 C825T polymorphism with IBS in patients with dyspepsia. We performed a case-control association study to determine whether these polymorphisms are associated with irritable bowel syndrome (IBS). The study aim was to compare allele and genotype frequencies between cases and controls for the 5-HTT LPR and the GNbeta3 C825T polymorphism. Cases were 50 GI outpatients; controls were 53 General Medicine outpatients matched to cases for age, gender and race at a major medical centre. Participants completed a questionnaire and donated blood. DNA was genotyped using polymerase chain reaction based assays. Eighty-two per cent of cases met Rome II criteria for IBS: 12% constipation-, 46% diarrhoea-, and 42% mixed-IBS. Genotype and allele frequencies for both polymorphisms did not differ between cases and controls. However, the allele frequency of the short (S) allele of the 5-HTT LPR polymorphism was greater in those with mixed-IBS compared with controls (68%vs 45%, P < 0.05). This study suggests that the 5-HTT LPR polymorphism may be associated with mixed-IBS, but not IBS overall. No association was observed for the GNbeta3 C825T polymorphism with IBS overall or subtypes. |
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Authors:
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Y A Saito; G R Locke; J M Zimmerman; G Holtmann; J P Slusser; M de Andrade; G M Petersen; N J Talley |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 19 ISSN: 1350-1925 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-13 Completed Date: 2007-07-16 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 465-70 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. saito.yuri@mayo.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Alleles Case-Control Studies Female Genetic Predisposition to Disease* Genotype Heterotrimeric GTP-Binding Proteins / genetics* Humans Irritable Bowel Syndrome / genetics* Male Middle Aged Polymerase Chain Reaction Polymorphism, Genetic Serotonin Plasma Membrane Transport Proteins / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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DK066271/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/G-protein beta3 subunit; 0/Serotonin Plasma Membrane Transport Proteins; EC 3.6.5.1/Heterotrimeric GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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