| A genetic association analysis of polymorphisms, rs2282695 and rs12373539, in the FOSB gene and papillary thyroid cancer. | |
| | |
MedLine Citation:
|
PMID: 23181129 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The FOSB gene is involved in cell proliferation, differentiation and transformation in several tumor types. We investigated whether coding single-nucleotide polymorphisms (cSNPs) and promoter SNPs of FOSB contribute to the development of papillary thyroid cancer (PTC). We also assessed the associations between FOSB SNPs and the clinicopathological characteristics of PTC. One coding SNP (rs2282695, Ala39Ala) and one promoter SNP (rs12373539, -158) in the FOSB gene were genotyped using direct sequencing in 94 PTC patients and 213 healthy controls. Genetic data were analyzed using SNPStats, HelixTree and SNPAnalyzer. PTC patients were dichotomized and compared with respect to clinicopathological characteristics of PTC. We detected an association between PTC and cSNP (rs2282695) in FOSB [codominant model 1 (C/C vs. G/C); OR=1.75; 95% CI, 1.04-2.94; P=0.024; codominant model 2 (C/C vs. G/G): OR=2.55; 95% CI, 1.15-5.64; P=0.045; dominant model: OR=1.89; 95% CI, 1.16-3.08; P=0.010; Log-additive model: OR=1.64; 95% CI, 1.15-2.35; P=0.007]. The G allele was a risk allele in the geno-type and allele analyses of cSNP (rs2282695) in the FOSB gene (OR=1.57; 95% CI, 1.10-2.24; P=0.012). A promoter SNP (rs12373539) in FOSB was associated with cervical lymph node metastasis of PTC [codominant model 1 (G/G vs. A/G): OR=0.23; 95% CI, 0.07-0.72; P=0.016; codominant model 2 (G/G vs. A/A): OR=0.21; 95% CI, 0.02-1.96; P=0.0.05; dominant model: OR=0.22; 95% CI, 0.08-0.66; P=0.004; overdominant model: OR=0.27; 95% CI, 0.09-0.84; P=0.02; log-additive model: OR=0.31; 95% CI, 0.12-0.78; P=0.006]. The A allele was a protective allele in the genotype and allele analyses of SNP (rs12373539) in the FOSB gene promoter (OR=0.34; 95% CI, 0.14-0.83; P=0.017). Variation in a FOSB cSNP (rs2282695) may be associated with risk of PTC. The FOSB promoter SNP (rs12373539) may be associated with lymph node metastasis of PTC. |
| | |
Authors:
|
Sang-Ah Han; Jeong-Yoon Song; Seon-Young Min; Won Seo Park; Mi-Ja Kim; Joo-Ho Chung; Kee Hwan Kwon |
Related Documents
:
|
22301439 - Evolution of hiv-1 genotype in plasma rna and peripheral blood mononuclear cells provir... 8780099 - Two new missense mutations in a non-jewish caucasian family with type 3 gaucher disease. 16162179 - Oca4: evidence for a founder effect for the p.d157n mutation of the matp gene in japane... 18449899 - Mutations in the glucose-6-phosphatase-alpha (g6pc) gene that cause type ia glycogen st... 16056219 - Higher prevalence of oca1 in an ethnic group of eastern india is due to a founder mutat... 20739809 - R778l, h1069q, and i1102t mutation study in neurologic wilson disease. 23720539 - Genomic mutation rates that neutralize adaptive evolution and natural selection. 19262599 - Frequent tet2 mutations in systemic mastocytosis: clinical, kitd816v and fip1l1-pdgfra ... 11264999 - International perspectives on antiretroviral resistance. nonnucleoside reverse transcri... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-6-08 |
Journal Detail:
|
Title: Experimental and therapeutic medicine Volume: 4 ISSN: 1792-1015 ISO Abbreviation: Exp Ther Med Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-11-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101531947 Medline TA: Exp Ther Med Country: - |
Other Details:
|
Languages: ENG Pagination: 519-523 Citation Subset: - |
Affiliation:
|
Department of Surgery, School of Medicine, Kyung Hee University, Seoul; |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association analysis of genetic polymorphisms of factor V, factor VII and fibrinogen ? chain genes w...
Next Document: Expression levels of multidrug resistance-associated protein 4 (MRP4) in human leukemia and lymphoma...