Document Detail

The genetic architecture of multiple myeloma.
MedLine Citation:
PMID:  22495321     Owner:  NLM     Status:  MEDLINE    
Based on the clinical features of myeloma and related malignancies of plasma cells, it has been possible to generate a model system of myeloma progression from a normal plasma cell through smouldering myeloma to myeloma and then plasma cell leukaemia. Using this model system we can study at which points the genetic alterations identified through whole-tumour molecular analyses function in the initiation and progression of myeloma. Further genetic complexity, such as intraclonal heterogeneity, and insights into the molecular evolution and intraclonal dynamics in this model system are crucial to our understandings of tumour progression, treatment resistance and the use of currently available and future treatments.
Gareth J Morgan; Brian A Walker; Faith E Davies
Publication Detail:
Type:  Journal Article; Review     Date:  2012-04-12
Journal Detail:
Title:  Nature reviews. Cancer     Volume:  12     ISSN:  1474-1768     ISO Abbreviation:  Nat. Rev. Cancer     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-07-09     Revised Date:  2012-10-23    
Medline Journal Info:
Nlm Unique ID:  101124168     Medline TA:  Nat Rev Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  335-48     Citation Subset:  IM    
Haemato-oncology Research Unit, Division of Molecular Pathology, The Institute of Cancer Research and Royal Marsden Hospital, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
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MeSH Terms
Clonal Evolution
Disease Progression
Genetic Heterogeneity*
Multiple Myeloma / genetics*,  pathology,  therapy
Plasma Cells / cytology
Tumor Markers, Biological / genetics
Reg. No./Substance:
0/Tumor Markers, Biological

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