| A genetic analysis of the Papillon-Lefèvre syndrome in a Jewish family from Cochin. | |
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MedLine Citation:
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PMID: 162525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Papillon-Lefèvre syndrome (PLS) is segregating in a large kindred of a Jewish isolate originating from Cochin, India. The frequency of the gene responsible for PLS among the Cochin Jews, 0.1, was estimated from the number of unrelated carriers in the isolate who married into the kindred. The obvious discrepancy between this apparently high gene frequency and the total absence of PLS in other kindreds of the isolate suggests that the syndrome may not behave as a simple autosomal recessive trait. |
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Authors:
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S Hacham-Zadeh; T Schaap; M M Cohen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of medical genetics Volume: 2 ISSN: 0148-7299 ISO Abbreviation: Am. J. Med. Genet. Publication Date: 1978 |
Date Detail:
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Created Date: 1984-01-26 Completed Date: 1984-01-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7708900 Medline TA: Am J Med Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 153-7 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Gene Pool* Genetics, Population* Genotype Heterozygote* Humans India / ethnology Israel Jews* Keratoderma, Palmoplantar / genetics* Male Papillon-Lefevre Disease / genetics* Pedigree |
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