Document Detail

The genesis of cognitive and behavioral deficits in premature graduates of intensive care.
MedLine Citation:
PMID:  12754453     Owner:  NLM     Status:  MEDLINE    
Increased survival of very low birth weight infants including those born at the cutting edge of viability is associated with substantial cognitive and behavioral deficits at follow-up that has extended into school age and adolescence. These problems have occurred as common in the presence or absence of neurosonographic abnormalities. Factors/events that may predispose to these problems include medical complications of prematurity i.e. chronic lung disease, recurrent episodes of apnea and bradycardia, transient hypothyroxinemia of prematurity, hyperbilirubinemia, nutritional deficiencies, medications used to treat such conditions i.e. glucorticoids, theophylline etc. and stress associated with prolonged hospitalization. With regard to the latter, attachment to multiple devices that limits infant provider interactions, high noise levels and constant light levels are considered to be of particular importance. Experimental evidence is presented that demonstrates the value of positive interactions between the subject and provider with regard to neurobehavioral outcome. Some suggested interventions include reducing noise levels and displacing it with music, modulating light exposure and enhancing infant parent interactions such as kangaroo care. Finally the important postnatal role of social influences on cognitive and behavioral outcomes is discussed.
J M Perlman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Minerva pediatrica     Volume:  55     ISSN:  0026-4946     ISO Abbreviation:  Minerva Pediatr.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-05-19     Completed Date:  2003-11-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0400740     Medline TA:  Minerva Pediatr     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  89-101     Citation Subset:  IM    
Department of Pediatrics, UT Southwestern Medical School, Dallas, TX 75390-9063, USA.
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MeSH Terms
Basal Ganglia / pathology
Brain Damage, Chronic / etiology
Child Behavior Disorders / etiology*
Cognition Disorders / etiology*
Follow-Up Studies
Hippocampus / pathology
Infant Care
Infant, Low Birth Weight / psychology
Infant, Newborn
Infant, Newborn, Diseases / psychology*,  therapy
Infant, Premature / psychology*
Infant, Very Low Birth Weight / psychology
Intensive Care Units, Neonatal*
Lighting / adverse effects
Noise / adverse effects
Stress, Physiological / complications
Survivors / psychology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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