Document Detail


The generation and maintenance of schedule-induced polydipsia in normal male rats without weight reduction.
MedLine Citation:
PMID:  9383129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experiment One demonstrated that two normal male Sprague-Dawley rats (approximately 60 days old) with free access to food and two control rats whose weights were held constant by dietary restriction acquired schedule-induced polydipsia (SIP) in daily 33-35 min sessions of fixed-time 60-s food delivery. Three of the rats showed rapid acquisition of SIP; the fourth acquired SIP more slowly and consumed less per session the other three rats. After a 36-40 day period without sessions, the constant-weight rats showed a 37% decrease in overall consumption due to reduced drinking bout length. The SIP of the free-feeding rats was not affected by the interruption. After 90-100 periodic food delivery sessions, all subjects consumed an average of 11.2-12.2 mL per session compared with 1.8-4.8 mL per session in baseline sessions with massed food presentations. Experiment Two replicated the acquisition phase of Experiment One using two non-weight-reduced rats of the age and size of those typically used in SIP studies (approximately 30 weeks old). Both acquired SIP, although one showed only a small average increase in consumption per session over baseline (2.8 mL/session under periodic food vs. 0.8 mL following massed-food presentations). Before weight reduction, the stronger drinker consumed approximately 8.8 mL per session compared with an average of 0.6 mL per session in baseline. After weight reduction, both exhibited strong SIP (18-19 mL per session in the final five sessions). This study demonstrates that weight reduction is not a necessary condition for the generation and maintenance of SIP in rats.
Authors:
J T Todd; L A Cunningham; A A Janes; J Mendelson; E K Morris
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  62     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1997-12-30     Completed Date:  1997-12-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1385-90     Citation Subset:  IM    
Affiliation:
Department of Psychology, Eastern Michigan University, Ypsilanti 48197, USA. PSY_TODD@ONLINE.EMICH.EDU
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MeSH Terms
Descriptor/Qualifier:
Animals
Conditioning, Operant / drug effects,  physiology
Drinking Behavior / physiology*
Food Deprivation / physiology
Male
Rats
Rats, Sprague-Dawley
Reinforcement Schedule
Weight Loss / physiology*
Grant Support
ID/Acronym/Agency:
HD07173-100111/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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