| A generalized model for swelling-controlled release systems. | |
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MedLine Citation:
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PMID: 20568207 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A generalized model has been developed for simultaneous transport of an active agent and an organic penetrant in a planar glassy polymer matrix. The active agent diffuses out of the matrix undergoing macromolecular chain relaxation and volume expansion due to absorption of the organic penetrant from the environment into the matrix. The swelling behavior of the polymer is characterized by a stress-induced drift velocity term "v" corresponding to the so-called case-II velocity. The change of volume due to the relaxation phenomenon is assumed instantaneous. The model incorporates convective transport of the two species induced by volume expansion and by stress gradient. The proposed phenomenological model reduces to a number of special cases depending on polymer-penetrant system behavior. |
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Authors:
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S K Singh; L T Fan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biotechnology progress Volume: 2 ISSN: 8756-7938 ISO Abbreviation: Biotechnol. Prog. Publication Date: 1986 Sep |
Date Detail:
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Created Date: 2010-06-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8506292 Medline TA: Biotechnol Prog Country: United States |
Other Details:
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Languages: eng Pagination: 145-56 Citation Subset: - |
Affiliation:
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Department of Chemical Engineering Durland Hall Kansas State University Manhattan, Kansas 66506. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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