| A generalized 4D image registration scheme for targeted radionuclide therapy dosimetry. | |
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MedLine Citation:
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PMID: 17627425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An iterative, generalized four-dimensional (4D) method is presented in this paper that allows simultaneous registration of a series of single-photon emission computed tomography (SPECT) scans acquired in the course of a radionuclide therapy or pretherapy tracer study. The method combines temporal information with voxel-based similarity criteria to carry out simultaneous registration of the SPECT scans. A polynomial function was fitted to the maximum counts of each tumor site over the 4D study. Each tumor site was normalized to its maximum on the reference scan, and a template 4D dataset was generated, employing the polynomial fitting and the normalization map. Then, each 3D scan was registered to the corresponding simulated scan, using a 3D similarity criterion. The correlation coefficient (CC), the mutual information (MI), and the sum-of-absolute differences (SAD) similarity criteria were employed. Simulated data, based on a head-neck (131)I-MIBG study, were used to compare the proposed method for 4D registration with sequential 3D registration. Sequential 3D registration resulted in residual registration errors of 3.5 +/- 2.5, 3.2 +/- 2.0, and 7.0 +/- 3.5 mm for the CC, MI, and SAD criteria respectively, whereas the corresponding 4D method gave errors of 2.4 +/- 1.6, 1.9 +/- 1.1, and 5.3 +/- 2.9 mm for the CC, MI, and SAD criteria, respectively. The 4D method was applied to (186)Re HEDP SPECT patient studies and registration was verified by a dual-cursor display tool. |
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Authors:
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Periklis Papavasileiou; Antigoni Divoli; Kostas Hatziioannou; Glenn D Flux |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer biotherapy & radiopharmaceuticals Volume: 22 ISSN: 1084-9785 ISO Abbreviation: Cancer Biother. Radiopharm. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-07-13 Completed Date: 2007-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9605408 Medline TA: Cancer Biother Radiopharm Country: United States |
Other Details:
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Languages: eng Pagination: 160-5 Citation Subset: IM |
Affiliation:
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Department of Medical Physics, Papageorgiou General Hospital, Thessaloniki, Greece. ppapavasileiou@yahoo.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Computer Simulation Humans Iodine Radioisotopes / administration & dosage*, therapeutic use* Neoplasms / radionuclide imaging, radiotherapy* Radiometry / methods Radiotherapy Planning, Computer-Assisted / methods* |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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