| A general role of hedgehog in the regulation of proliferation. | |
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MedLine Citation:
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PMID: 17245127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Hedgehog (Hh) pathway regulates proliferation in a variety of tissues, however its specific effects on the cell cycle are unclear. During retinal proliferation in particular, the role of Hh has been controversial, with studies variably suggesting a stimulatory or an inhibitory effect on proliferation. Our recent data provide an underlying mechanism, which reconciles these different views. We showed that Hh signaling in the retina accelerates the G(1) and G(2) phases of the cell cycle and then pushes these rapidly dividing cells out of the cell cycle prematurely. From this and other evidence, we propose that Hh converts quiescent retinal stem cells into fast-cycling transient amplifying progenitors that are closer to cell cycle exit and differentiation. This is, we suggest, likely to be a general role of Hh in the nervous system and other tissues. This function of Hh in cell cycle kinetics and cell cycle exit may have implications for tumorigenesis and brain evolution. |
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Authors:
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Michalis Agathocleous; Morgane Locker; William A Harris; Muriel Perron |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-01-19 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 6 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-03-01 Completed Date: 2007-04-09 Revised Date: 2007-08-13 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 156-9 Citation Subset: IM |
Affiliation:
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Department of Physiology, Development and Neuroscience, Cambridge University, Cambridge, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology Cell Differentiation / physiology Cell Proliferation* Hedgehog Proteins / physiology* Humans Signal Transduction / physiology |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Hedgehog Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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