Document Detail


A general preparation of protected phosphoamino acids.
MedLine Citation:
PMID:  22356680     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Fmoc-O-benzyl-l-phosphoserine is an important building block in the synthesis of Forigerimod, a phosphopeptide being investigated for Systemic Lupus Erythematosus (SLE). An efficient one-pot process was developed using inexpensive, readily available starting materials. This general procedure was used to prepare a variety of protected phosphoamino acids.
Authors:
Daniel E Petrillo; Dale R Mowrey; Shawn P Allwein; Roger P Bakale
Publication Detail:
Type:  Journal Article     Date:  2012-02-22
Journal Detail:
Title:  Organic letters     Volume:  14     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1206-9     Citation Subset:  IM    
Affiliation:
Chemical Process Research and Development, Cephalon Inc., 383 Phoenixville Pike, Malvern, Pennsylvania 19355, United States.
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