Document Detail


A general method for evaluating incubation of sucrose craving in rats.
MedLine Citation:
PMID:  22083029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For someone on a food-restricted diet, food craving in response to food-paired cues may serve as a key behavioral transition point between abstinence and relapse to food taking. Food craving conceptualized in this way is akin to drug craving in response to drug-paired cues. A rich literature has been developed around understanding the behavioral and neurobiological determinants of drug craving; we and others have been focusing recently on translating techniques from basic addiction research to better understand addiction-like behaviors related to food. As done in previous studies of drug craving, we examine sucrose craving behavior by utilizing a rat model of relapse. In this model, rats self-administer either drug or food in sessions over several days. In a session, lever responding delivers the reward along with a tone+light stimulus. Craving behavior is then operationally defined as responding in a subsequent session where the reward is not available. Rats will reliably respond for the tone+light stimulus, likely due to its acquired conditioned reinforcing properties. This behavior is sometimes referred to as sucrose seeking or cue reactivity. In the present discussion we will use the term "sucrose craving" to subsume both of these constructs. In the past decade, we have focused on how the length of time following reward self-administration influences reward craving. Interestingly, rats increase responding for the reward-paired cue over the course of several weeks of a period of forced-abstinence. This "incubation of craving" is observed in rats that have self-administered either food or drugs of abuse. This time-dependent increase in craving we have identified in the animal model may have great potential relevance to human drug and food addiction behaviors. Here we present a protocol for assessing incubation of sucrose craving in rats. Variants of the procedure will be indicated where craving is assessed as responding for a discrete sucrose-paired cue following extinction of lever pressing within the sucrose self-administration context (Extinction without cues) or as responding for sucrose-paired cues in a general extinction context (Extinction with cues).
Authors:
Jeffrey W Grimm; Jesse Barnes; Kindsey North; Stefan Collins; Rachel Weber
Related Documents :
2292509 - Development of the statocyst in aplysia californica. i. observations on statoconial dev...
17656389 - Antimicrobials and animal health: a fascinating nexus.
11308129 - Drought associated poisoning of cattle in south texas by the high quality forage legume...
25134959 - Identification of drug-resistant salmonella from food handlers at the university of gon...
20431869 - Evidence of natural occurrence of the banned antibiotic chloramphenicol in herbs and gr...
12646009 - Impact of antimicrobial resistance on regulatory policies in veterinary medicine: statu...
22361199 - Development of marine probiotics: prospects and approach.
2147189 - The relationship of affective state to dietary preference: winter depression and light ...
23666329 - Prop is required for the survival of desiccated salmonella enterica serovar typhimurium...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Video-Audio Media     Date:  2011-11-04
Journal Detail:
Title:  Journal of visualized experiments : JoVE     Volume:  -     ISSN:  1940-087X     ISO Abbreviation:  J Vis Exp     Publication Date:  2011  
Date Detail:
Created Date:  2011-11-15     Completed Date:  2012-01-30     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  101313252     Medline TA:  J Vis Exp     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e3335     Citation Subset:  IM    
Affiliation:
Department of Psychology and Program in Behavioral Neuroscience, Western Washington University, USA. jeff.grimm@wwu.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Association Learning*
Behavior, Addictive*
Behavior, Animal*
Conditioning, Classical
Feeding Behavior*
Food Preferences*
Male
Models, Animal
Rats
Rats, Long-Evans
Sucrose / administration & dosage*
Grant Support
ID/Acronym/Agency:
R15 DA016285-02/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
57-50-1/Sucrose
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of anemia on hepatotoxicity of HAART in HIV patients in Benin city.
Next Document:  The Role of Atrial Natriuretic Peptide in Modulating Cardiac Electrophysiology.