| The general anesthetic sevoflurane affects the expression of clock gene mPer2 accompanying the change of NAD(+) level in the suprachiasmatic nucleus of mice. | |
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MedLine Citation:
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PMID: 21195744 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Sevoflurane is an anesthetic for the general anesthesia. In this study, we showed that sevoflurane anesthesia affects the expression of mouse Per2 (mPer2), which is a clock gene in the brain which is considered the organ where the anesthetics act in. 64.5% of mPer2 circadian expression was repressed under anesthesia in the suprachiasmatic nucleus (SCN) of the brain. After recovering from the anesthesia, the repressed mPer2 expression was restored to the same level as in non anesthesia-treated mice. This repression pattern was also observed in the subsequent phases of diurnal mPer2 expression. However, obvious phase-shift in the mPer2 expression was not showed in this study. On the other hand, the behavior analysis in this experiment exhibited that the phases in the circadian behavioral rhythm were shifted backwards. We also measured the NAD(+) level in the SCN, which was a mediator regulating the mPer2 expression. Then, significant increase of NAD(+) was detected under the anesthesia. These results indicate that the anesthesia induces the increase of NAD(+), and consequently leads to the repression of mPer2 expression and modifies the circadian expression pattern and diurnal behavioral rhythm of mice. Furthermore, the modification of mPer2 expression by the anesthesia is considered to affect various gene expressions. |
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Authors:
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Yumiko Ohe; Norio Iijima; Kana Kadota; Atsuhiro Sakamoto; Hitoshi Ozawa |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-31 |
Journal Detail:
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Title: Neuroscience letters Volume: - ISSN: 1872-7972 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Sendagi 1-1-5, Bunkyo-ku, Tokyo 113-8602, Japan; Department of Anesthesiology, Graduate School of Medicine, Nippon Medical School, Sendagi 1-1-5, Bunkyo-ku, Tokyo 113-8602, Japan. |
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