Document Detail


A gene that encodes for a leukemia-associated phosphoprotein (p18) maps to chromosome bands 1p35-36.1.
MedLine Citation:
PMID:  2278968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cytosolic protein p18 which is expressed in increased amounts in acute leukemia cells is variably phosphorylated as a function of growth and differentiation. Proteins with identical amino acid sequence were independently found to be highly expressed in normal brain tissue and neuroendocrine tumor cells. Here we described the mapping of the recently cloned p18 gene to chromosome 1, band p35-36.1 by Southern blot analysis of human-rodent somatic cell hybrid DNA and by chromosome in situ hybridization using a p18 genomic probe. This region of the distal short arm of chromosome 1 is a frequent site of deletions or loss of heterozygosity in tumors derived from neural crest cells, particularly neuroblastomas and melanomas. The high levels of expression of p18 in brain and neuroendocrine tumor cells, its possible role in growth regulation, and its chromosomal location in a region frequently deleted in neuroectodermal tumors suggest that this gene may be involved in common genetic events occurring in these tumors.
Authors:
A C Ferrari; H N Seuanez; S M Hanash; G F Atweh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  2     ISSN:  1045-2257     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1991-03-08     Completed Date:  1991-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  125-9     Citation Subset:  IM    
Affiliation:
Division of Hematology and Oncology, VA Medical Center, Brooklyn, New York 11209.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Chemistry
Chromosome Mapping
Chromosomes, Human, Pair 1*
DNA / genetics
Genes, Neoplasm*
Humans
Hybrid Cells
Leukemia / genetics*
Neoplasm Proteins / genetics*
Neuroblastoma / genetics
Neurosecretory Systems / chemistry
Phosphoproteins / genetics*
Phosphorylation
Protein Processing, Post-Translational
Rodentia
Sequence Homology, Nucleic Acid
Chemical
Reg. No./Substance:
0/Neoplasm Proteins; 0/Phosphoproteins; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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