Document Detail

The gene for the retinal pigment epithelium-specific protein RPE65 is localized to human 1p31 and mouse 3.
MedLine Citation:
PMID:  8034329     Owner:  NLM     Status:  MEDLINE    
The human and murine chromosomal localization for the gene for the retinal pigment epithelium-specific protein RPE65 was determined. Using interspecific backcross analysis, we mapped Rpe65 to the distal end of mouse chromosome 3. In the human, using a human-hamster hybrid panel, RPE65 was mapped to chromosome 1. By the use of fluorescence in situ hybridization, this localization was refined to 1p31. The mouse and human loci for this potential candidate gene for hereditary retinal disease do not match those of any known disease in mouse or man.
C P Hamel; N A Jenkins; D J Gilbert; N G Copeland; T M Redmond
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  20     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-08-18     Completed Date:  1994-08-18     Revised Date:  2012-05-28    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  509-12     Citation Subset:  IM    
Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892.
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MeSH Terms
Carrier Proteins
Chromosome Mapping*
Chromosomes, Human, Pair 1*
Eye Proteins / genetics*
Genetic Markers
Hominidae / genetics*
Hybrid Cells
Mice / genetics*
Pigment Epithelium of Eye / metabolism*
Retinal Diseases / genetics
Grant Support
Reg. No./Substance:
0/Carrier Proteins; 0/Eye Proteins; 0/Genetic Markers; 0/Proteins; EC isomerohydrolase

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