Document Detail


A gene linked to the heavy-chain allotype I alpha (1a) controls for the expression of idiotype Ox-r1 in the rat.
MedLine Citation:
PMID:  6811425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A rabbit antiserum prepared against purified anti-2-phenyl-oxazolone (phOx) antibodies of AVN rats detects a common idiotype called Ox-r1. This idiotype was also present in anti-phOx antibodies of AS and (AS x LEP)F1 hybrid rats but not in the antibodies of LEP rats. Antisera of (AS x LEP) x LEP backcross rats either resembled F1 hybrid sera (7 rats) or LEP sera (8 rats) in the idiotype assay. All idiotype-positive backcross rats but none of the idiotype negative backcross rats had the I alpha (1) allotype a. The likelihood that such a distribution was due to a chance is approximately 0.0002. The data suggest that the presence of idiotype Ox-r1 in the antisera of AS rats and their progeny is controlled by a gene (or genes) linked to the 1g heavy-chain allotype locus I alpha (1).
Authors:
J Pelkonen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunology letters     Volume:  5     ISSN:  0165-2478     ISO Abbreviation:  Immunol. Lett.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  19-22     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Anti-Idiotypic / analysis
Female
Hybridization, Genetic
Immunoglobulin Allotypes / genetics*
Immunoglobulin Heavy Chains / genetics*
Immunoglobulin Idiotypes / genetics*
Immunoglobulin Light Chains / genetics*
Isoelectric Focusing
Male
Radioimmunoassay
Rats / genetics*
Chemical
Reg. No./Substance:
0/Antibodies, Anti-Idiotypic; 0/Immunoglobulin Allotypes; 0/Immunoglobulin Heavy Chains; 0/Immunoglobulin Idiotypes; 0/Immunoglobulin Light Chains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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