Document Detail

A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas.
MedLine Citation:
PMID:  8649854     Owner:  NLM     Status:  MEDLINE    
We have identified a gene, called ARP for Arginine-rich protein, in human chromosomal band 3p21. It is approximately 600 Kb telomeric to the ACY1 locus (Miller et al., 1989) and encodes a previously unidentified 234 amino acid long, highly basic protein. This gene is highly conserved at the DNA and RNA level. It is found in all species including hamster, rat, mouse, bovine and yeast. We have detected a point mutation (ATG50 to AGG) or deletion of ATG50 in 10 of 21 sporadic renal cell carcinomas. The mutable region is in an imperfect trinucleotide repeat in the coding region which is non-polymorphic among 50 normal individuals examined. The point mutation (ATG50 to AGG) or deletion of codon 50 removes a methionine and increases the stretch of arginines encoded by the AGG repeats in the ARP gene.
V Shridhar; S Rivard; R Shridhar; C Mullins; L Bostick; W Sakr; D Grignon; O J Miller; D I Smith
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Oncogene     Volume:  12     ISSN:  0950-9232     ISO Abbreviation:  Oncogene     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-07-22     Completed Date:  1996-07-22     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1931-9     Citation Subset:  IM    
Department of Molecular Biology and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Carcinoma, Renal Cell / genetics*
Chromosomes, Human, Pair 3*
Conserved Sequence*
DNA, Complementary
DNA, Satellite
Hybrid Cells
Kidney Neoplasms / genetics*
Molecular Sequence Data
Point Mutation*
Proteins / genetics*
Transcription, Genetic
Tumor Cells, Cultured
Grant Support
Reg. No./Substance:
0/Codon; 0/DNA, Complementary; 0/DNA, Satellite; 0/MANF protein, human; 0/Proteins

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