| A gene expression signature identifies two prognostic subgroups of basal breast cancer. | |
| | |
MedLine Citation:
|
PMID: 20490655 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Prognosis of basal breast cancers is poor but heterogeneous. Medullary breast cancers (MBC) display a basal profile, but a favorable prognosis. We hypothesized that a previously published 368-gene expression signature associated with MBC might serve to define a prognostic classifier in basal cancers. We collected public gene expression and histoclinical data of 2145 invasive early breast adenocarcinomas. We developed a Support Vector Machine (SVM) classifier based on this 368-gene list in a learning set, and tested its predictive performances in an independent validation set. Then, we assessed its prognostic value and that of six prognostic signatures for disease-free survival (DFS) in the remaining 2034 samples. The SVM model accurately classified all MBC samples in the learning and validation sets. A total of 466 cases were basal across other sets. The SVM classifier separated them into two subgroups, subgroup 1 (resembling MBC) and subgroup 2 (not resembling MBC). Subgroup 1 exhibited 71% 5-year DFS, whereas subgroup 2 exhibited 50% (P = 9.93E-05). The classifier outperformed the classical prognostic variables in multivariate analysis, conferring lesser risk for relapse in subgroup 1 (HR = 0.52, P = 3.9E-04). This prognostic value was specific to the basal subtype, in which none of the other prognostic signatures was informative. Ontology analysis revealed effective immune response (IR), enhanced tumor cell apoptosis, elevated levels of metastasis-inhibiting factors and low levels of metastasis-promoting factors in the good-prognosis subgroup, and a more developed cell migration system in the poor-prognosis subgroup. In conclusion, based on this 368-gene SVM model derived from an MBC signature, basal breast cancers were classified in two prognostic subgroups, suggesting that MBC and basal breast cancers share similar molecular alterations associated with aggressiveness. This signature could help define the prognosis, adapt the systemic treatment, and identify new therapeutic targets. |
| | |
Authors:
|
Renaud Sabatier; Pascal Finetti; Nathalie Cervera; Eric Lambaudie; Benjamin Esterni; Emilie Mamessier; Agnès Tallet; Christian Chabannon; Jean-Marc Extra; Jocelyne Jacquemier; Patrice Viens; Daniel Birnbaum; François Bertucci |
Related Documents
:
|
1457515 - Biology of breast cancer and its clinical implications. 18641005 - Molecular profiling including epidermal growth factor receptor and p21 expression in hi... 9294625 - Vascular density is a predictor of cancer-specific survival in prostatic carcinoma. 17160155 - Risk and prognostic factors for differentiated thyroid cancer. 8168475 - Effects of appearance-based admonitions against sun exposure on tanning intentions in y... 3093695 - Alpha-difluoromethylornithine enhancement of 14c-putrescine uptake by an androgen-depen... |
Publication Detail:
|
Type: Journal Article Date: 2010-05-21 |
Journal Detail:
|
Title: Breast cancer research and treatment Volume: 126 ISSN: 1573-7217 ISO Abbreviation: Breast Cancer Res. Treat. Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-03-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8111104 Medline TA: Breast Cancer Res Treat Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 407-20 Citation Subset: IM |
Affiliation:
|
Département d'Oncologie Moléculaire, Centre de Recherche en Cancérologie de Marseille, UMR891 Inserm, Institut Paoli-Calmettes, Marseille, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: TMS, a chemically modified herbal derivative of resveratrol, induces cell death by targeting Bax.
Next Document: Functional electrical stimulation of lower limbs in patients with chronic heart failure.