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The gene expression of TWEAK / Fn14 and IP-10 / CXCR3 in glomerulus and tubulo-interstitium of patients with lupus nephritis.
MedLine Citation:
PMID:  21303425     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective We study the role of TNF-like weak inducer of apoptosis (TWEAK)/Fn14 and interferon-inducible protein (IP-10) / CXCR3 axis in the pathogenesis of lupus nephritis. Methods We quantified the mRNA expression of TWEAK, Fn14, IP-10 and CXCR3 in glomerulus and tubulo-interstitium of 42 patients with lupus nephritis (LN group) and 10 healthy controls. Results As compared to controls, LN patients had higher glomerular expression of TWEAK and Fn14, but glomerular CXCR3 expression was lower in the LN group. Similarly, LN group had higher tubulointerstitial expression of TWEAK and Fn14, but lower tubulointerstitial expression of CXCR3, than controls. Glomerular TWEAK expression of class V nephritis was significantly higher than class IV nephritis. Glomerular expression of CXCR3 significantly correlated with proteinuria (r = -0.532; p = 0.019), whereas tubulointerstitial CXCR3 significantly correlated with serum creatinine (r = -0.447; p = 0.029). Conclusion In patients with lupus nephritis, there is an increase in intra-renal expression of TWEAK and Fn14, and a decrease in CXCR3 expression. Intra-renal expression of CXCR3 correlates with proteinuria and renal function. Our findings suggest that TWEAK/Fn14 and IP-10/CXCR3 axis may contribute to the pathogenesis of lupus nephritis.
Authors:
Jianxin Lu; Bonnie Ching-Ha Kwan; Fernand Mac-Moune Lai; Paul Cheung-Lung Choi; Lai-Shan Tam; Edmund Kwok-Ming Li; Kai-Ming Chow; Gang Wang; Philip Kam-Tao Li; Cheuk-Chun Szeto
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-8
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1797     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Nephrology © 2011 Asian Pacific Society of Nephrology.
Affiliation:
Department of Medicine & Therapeutics and Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
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