| A gel-forming poly-L: -guluronic acid produced from no guluronate-rich marine algae using new hydrolysis method: test for endovascular embolization. | |
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MedLine Citation:
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PMID: 19399590 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To prepare a gel-forming poly-L-guluronic acid (Poly-G) from no guluronate-rich Laminaria japonica, a new hydrolysis method was employed with a lower HCl concentration (0.025-0.15 M) and a shorter treatment time (5 min). The Poly-Gs were set to measure purity, presence of poly-L-guluronic block, molecular weight distribution, polymer yield, viscosity, and compressive gel strength. Finally, the Poly-G was tested to embolize the renal vascular system by using a rabbit model and angiography. Optimized Poly-G could be selected with respect to wt% concentration, polymer yield, gel-forming stability, viscosity, and gel strength as an endovascular embolizing agent. Overall, 0.4-0.6% of 0.03 M-Poly-G obtained from acid treatment with 0.03 M of HCl had molecular weights greater than 80 kDa, and the best gelling capacity with an injectable viscosity (30-120 cP). It was successfully delivered into the vascular bed of a rabbit kidney and was shown angiographically to embolize the renal vascular system. |
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Authors:
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Hyun Mee Lee; Yeon-Hee Yoon; Woo-Back Lee; Jong-Ki Kim |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-28 |
Journal Detail:
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Title: Journal of materials science. Materials in medicine Volume: 20 ISSN: 1573-4838 ISO Abbreviation: J Mater Sci Mater Med Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-11 Completed Date: 2009-12-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: United States |
Other Details:
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Languages: eng Pagination: 1917-26 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Yeungnam University, Gyeongsan, South Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algae Angiography Animals Biocompatible Materials / chemistry Circular Dichroism Embolization, Therapeutic / instrumentation* Gels* Hexuronic Acids / chemistry* Hydrochloric Acid / chemistry Hydrolysis Kidney / metabolism* Polymers / chemistry Rabbits Time Factors Viscosity |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Gels; 0/Hexuronic Acids; 0/Polymers; 15769-56-9/guluronic acid; 7647-01-0/Hydrochloric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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