Document Detail


The gastrulation defective gene of Drosophila melanogaster is a member of the serine protease superfamily.
MedLine Citation:
PMID:  9618496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The establishment of dorsal-ventral polarity in the oocyte involves two sets of genes. One set belongs to the gurken-torpedo signaling pathway and affects the development of the egg chorion as well as the polarity of the embryo. The second set of genes affects only the dorsal-ventral polarity of the embryo but not the eggshell. gastrulation defective is one of the earliest acting of this second set of maternally required genes. We have cloned and characterized the gastrulation defective gene and determined that it encodes a protein structurally related to the serine protease superfamily, which also includes the Snake, Easter, and Nudel proteins. These data provide additional support for the involvement of a protease cascade in generating an asymmetric signal (i.e., asymmetric Spätzle activity) during establishment of dorsal-ventral polarity in the Drosophila embryo.
Authors:
K D Konrad; T J Goralski; A P Mahowald; J L Marsh
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  95     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-07-09     Completed Date:  1998-07-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6819-24     Citation Subset:  IM    
Affiliation:
Developmental Biology Center and the Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92697-2300, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/U09808
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Cloning, Molecular
Drosophila melanogaster / embryology*,  genetics*
Gene Expression Regulation, Developmental*
Genes, Insect*
Insect Proteins / genetics
Molecular Sequence Data
Sequence Alignment
Serine Endopeptidases / genetics*
Grant Support
ID/Acronym/Agency:
GM28972/GM/NIGMS NIH HHS; HD17607/HD/NICHD NIH HHS; P01 HD27173/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Insect Proteins; EC 3.4.21.-/Serine Endopeptidases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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