Document Detail

A gas chromatographic/mass spectrometric study of the trimethylsilylation of ethambutol and a tablets assay method based on the trimethylsilyl derivative.
MedLine Citation:
PMID:  7142357     Owner:  NLM     Status:  MEDLINE    
The trimethylsilylation of ethambutol base and ethambutol hydrochloride was studied by means of GC/MS. The derivatisation is shown to proceed in two distinct steps, and the second derivative is identified, by both chemical ionisation and electron impact Ms, and the di-trimethylsilyl ethambutol. Most of the major mass fragments observed are assigned. A tablets assay method, based on the direct trimethylsilylation of ethambutol hydrochloride in tablets, is also described. It is simple, rapid, and unaffected by the presence of the common excipients in the tablets.
T L Ng
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of chromatographic science     Volume:  20     ISSN:  0021-9665     ISO Abbreviation:  J Chromatogr Sci     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173225     Medline TA:  J Chromatogr Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  479-82     Citation Subset:  IM    
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MeSH Terms
Biological Availability
Ethambutol / analysis*
Gas Chromatography-Mass Spectrometry
Silicon / analysis*
Tablets / analysis
Trimethylsilyl Compounds / analysis*
Reg. No./Substance:
0/Tablets; 0/Trimethylsilyl Compounds; 74-55-5/Ethambutol; 7440-21-3/Silicon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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