| A gas chromatographic/mass spectrometric study of the trimethylsilylation of ethambutol and a tablets assay method based on the trimethylsilyl derivative. | |
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MedLine Citation:
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PMID: 7142357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The trimethylsilylation of ethambutol base and ethambutol hydrochloride was studied by means of GC/MS. The derivatisation is shown to proceed in two distinct steps, and the second derivative is identified, by both chemical ionisation and electron impact Ms, and the di-trimethylsilyl ethambutol. Most of the major mass fragments observed are assigned. A tablets assay method, based on the direct trimethylsilylation of ethambutol hydrochloride in tablets, is also described. It is simple, rapid, and unaffected by the presence of the common excipients in the tablets. |
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Authors:
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T L Ng |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of chromatographic science Volume: 20 ISSN: 0021-9665 ISO Abbreviation: J Chromatogr Sci Publication Date: 1982 Oct |
Date Detail:
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Created Date: 1983-01-19 Completed Date: 1983-01-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0173225 Medline TA: J Chromatogr Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 479-82 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Availability Ethambutol / analysis* Gas Chromatography-Mass Spectrometry Silicon / analysis* Tablets / analysis Trimethylsilyl Compounds / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Tablets; 0/Trimethylsilyl Compounds; 74-55-5/Ethambutol; 7440-21-3/Silicon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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