Document Detail


A gas chromatographic-mass spectrometric assay for nine hydroxyphenolic acids in uremic serum.
MedLine Citation:
PMID:  487594     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A mass fragmentographic method for the determination of m-hydroxybenzoic acid, p-hydroxybenzoic acid, o-hydroxyphenylacetic acid, m-hydroxyphenylacetic acid, p-hydroxyphenylacetic acid, vanillic acid, p-hydroxymandelic acid, homovanillic acid and vanilmandelic acid in uremic serum is described. The hydroxyphenolic acids were extracted from one ml of serum ultrafiltrate. After trimethylsilylation, the extract was analyzed by a gas chromatograph-mass spectrometer. Concentrations of nine hydroxyphenolic acids are higher in uremic serum. In particular, p-hydroxybenzoic acid and p-hydroxyphenylacetic acid are markedly increased in uremic serum. The influence of hemodialysis on the hydroxyphenolic acids was studied by quantitating the acids before and after hemodialysis.
Authors:
T Niwa; T Ohki; K Maeda; A Saito; K Ohta; K Kobayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  96     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1979-12-20     Completed Date:  1979-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  247-54     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Female
Gas Chromatography-Mass Spectrometry
Humans
Hydroxy Acids / blood*
Hydroxybenzoic Acids / blood
Male
Phenylacetates / blood
Uremia / blood*
Chemical
Reg. No./Substance:
0/Hydroxy Acids; 0/Hydroxybenzoic Acids; 0/Phenylacetates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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