Document Detail

The garden snail (Helix aspersa) as a bioindicator of organophosphorus exposure: effects of dimethoate on survival, growth, and acetylcholinesterase activity.
MedLine Citation:
PMID:  11521821     Owner:  NLM     Status:  MEDLINE    
The garden snail (Helix aspersa) is currently used as bioindicator of metallic pollution. Our objective was to extend its use to organic chemicals by studying the effects and tissue concentrations of the organophosphorus pesticide dimethoate following dietary uptake. After exposure for four weeks to increasing doses of pesticide in the diet, the median lethal concentration (LC50) was determined to be 3,700 microg/g food. Clinical signs indicated a no-observed-effect concentration of 100 microg/g and a lowest-observed-effect concentration of 250 microg/g. The growth parameters were decreased with increasing exposure to the pesticide. The median effective concentration (EC50), which was evaluated based on both shell diameter and dry weight inhibitions, was 665 and 424 microg/g, respectively, and the EC10 was 180 and 145 microg/g, respectively. Accumulation in the viscera was related to the amount of dimethoate in the food. The bioconcentration factors were low (>6 x 10(-3)). Acetylcholinesterase (AChE) activity was strongly decreased (80% from 250 microg/g). In conclusion, we demonstrated that the species H. aspersa could be a useful sentinel organism for organophosphorus contamination surveys. Among the effects measured, the inhibition of AChE activities and clinical signs were the most sensitive, followed by the growth parameters. These results confirm the suitability of the garden snail for development of sublethal toxicity tests using primary consumers and aboveground organisms.
M Coeurdassier; M Saint-Denis; A Gomot-de Vaufleury; D Ribera; P M Badot
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental toxicology and chemistry / SETAC     Volume:  20     ISSN:  0730-7268     ISO Abbreviation:  Environ. Toxicol. Chem.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-08-27     Completed Date:  2002-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8308958     Medline TA:  Environ Toxicol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1951-7     Citation Subset:  IM    
Laboratoire de Biologie et Ecophysiologie, Université de Franche-Comté, Besançon, France.
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MeSH Terms
Acetylcholinesterase / drug effects,  metabolism*
Biological Markers
Dimethoate / adverse effects*,  pharmacokinetics
Environmental Monitoring
Helix (Snails)*
Insecticides / adverse effects*,  pharmacokinetics
Population Dynamics
Tissue Distribution
Toxicity Tests
Reg. No./Substance:
0/Biological Markers; 0/Insecticides; 60-51-5/Dimethoate; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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